Lipid-mediated activation of protein kinases during cell polarization (A05)

• Subject Area: Cell Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

We study the dynamic distribution of distinct lipids within subdomains of the plasma membrane using mammalian cell culture models and Drosophila in vivo experiments. Furthermore, we investigate the detailed mechanisms of LKB1 and PAR-1 regulation by phospholipids at cellular interfaces and their impact on cell polarity and signaling.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Michael Krahn, Ph.D.