Spatial and temporal targeting of membrane-bound mPGES-1 and FLAP / 5-LO by dual inhibitors employing polymer-based nanocarriers (A04)

• Subject Area: Pharmacy
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

Project A04 aims at establishing novel and more effective drugs for resolving inflammation, specifically of dual inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase-activating protein (FLAP) or 5-lipoxygenase (5-LO). Improved bioavailability and target-specific delivery of the drug will be realised employing polymer particles as nanocarriers. Drug delivery at site will be investigated utilising advanced fluorescence microscopy both in monocyte-derived macrophages and more complex biosystems.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Christian Eggeling, since 7/2021; Professor Dr. Ulrich S. Schubert; Professor Dr. Oliver Werz