SFB 1349:  Fluorine-Specific Interactions: Fundamentals and Functions

The aim of the CRC 1349 is to understand, control and apply the complex interactions that can arise from fluorinated groups in chemical systems and are denoted as Fluorine-Specific interactions. This includes systems with H∙∙∙F Interactions, with Acceptorcontrolled Properties, e.g., in fluorinated Lewis-acids, and Interactions with fluorous Systems such as those encountered between (per-)fluorinated alkane groups. Interactions on a molecu-lar scale differ significantly from collective interactions due to mutually influencing, non-additive effects that exist on surfaces or in liquid phases. Therefore, the investigated systems range from single molecules through various ensembles to condensed phases or interfaces. The CRC focuses on the influences of the investigated interactions on a wide range of physicochemical properties and chemical reactivities. This includes the effects of Fluorine-Specific interactions on the properties of functional materials, the mechanisms of catalytic processes, and the function of biochemical systems and pharmaceuticals. For this purpose, the comprehensive expertise of the working groups involved in synthesis/biosynthesis, analysis/spectroscopy, and theory/modeling is linked in a complementary and synergistic manner to establish an understanding of Fluorine-Specific interactions, their con-ceptual foundation, and their numerous consequences and to translate all these into functional systems.

DFG Programme Collaborative Research Centres

• A01 - Control of C-F-Bond Activation and Fluorination Reactions through Fluorine-Specific Interactions in the Coordination Sphere of Metal Compounds (Project Head Braun, Thomas )
• A03 - Pentafluorophosphates and Other Hyperfluorinated Fragments as Biomimetics of Phosphopeptides, Phos-phoproteins, and Pyrophosphates (Project Head Rademann, Jörg )
• A04 - Control of Protein Folding and Protein Self Assembling through Fluorine-Specific Interactions (Project Head Koksch, Beate )
• A05 - Modeling Fluorine-Specific Interactions in Protein-Environments (Project Head Keller, Bettina )
• A07 - Influence of Fluoride Ions on Fluid-Melt-Mineral Interactions in Ore Forming Processes (Project Head John, Timm )
• A08 - Fluorine-Specific Interactions for the Detection and Reversible Immobilization of Perfluorinated Com-pounds (Project Heads Emmerling, Franziska ;  Hecht, Stefan )
• A09 - Nonlinear Infrared Short-Time Spectroscopy for the Characterization of Fluorine-Specific Interactions: Structure, Dynamics and Catalytic Determinants of H∙∙∙F-Networks on Fluorido Complexes and Metallo-peptides (Project Head Horch, Marius )
• B01 - Cooperative Lewis Pairs based on fluorinated aluminum- and bismuth-containing acceptor units (Project Head Limberg, Christian )
• B03 - Fluorine-Specific Interactions of F2, HF, and F− (Project Head Hasenstab-Riedel, Sebastian )
• B04 - Fluorinated Aluminum Compounds as Lewis Acids for the Activation of Small Molecules (Project Heads Braun, Thomas ;  Hasenstab-Riedel, Sebastian )
• B06 - Theoretical Investigation of Fluorine-Specific Interactions in Condensed Metal Fluorides and Polyfluorine Anions (Project Head Paulus, Beate )
• B08 - Adjusting the Oxidation Power of Organic Electron Acceptors by Interactions with Fluorinated Brønsted- and Lewis Acids (Project Head Malischewski, Moritz )
• C02 - Quantum Chemical Studies of Fluorine-Specific Interactions: Binding Analyses, Advanced Solvent Models, and Spectroscopic Properties. (Project Head Kaupp, Martin )
• C04 - Microscopic Mechanisms of Superhydrophobicity and Superlubricity of Fluorinated Surfaces (Project Head Netz, Roland )
• C05 - Fluorinated Compounds as Vibrational-Spectroscopic Interface Sensors (Project Head Heberle, Joachim )
• C06 - Fluorine-Specific Interactions at Interfaces (Project Heads Böttcher, Christoph ;  Haag, Rainer ;  Schalley, Christoph A. )
• C07 - Access to Degradable Perfluorinated Polycarbonates by Ring-Opening Copolymerization (Project Head Plajer, Ph.D., Alex )
• C08 - Evaluation of Novel Adsorber Materials for Environmentally Relevant Perfluorinated Compounds (Project Heads Haag, Rainer ;  Meermann, Björn )
• C09 - Fluorine-Specific Interactions for the Enhancement of Cellular Uptake of Proteins and Drug Conjugates into Living Cells (Project Head Hackenberger, Christian )
• DMGK - Integrated Research Training Network (Project Heads Hopkinson, Matthew ;  Malischewski, Moritz ;  Paulus, Beate )
• Z - Administration of the Cooperative Research Center (Project Head Hasenstab-Riedel, Sebastian )

• A02 - Photocatalyst Luminescence Quenching as a Tool for Investigating Hydrogen Bonding and Lewis Acid-Induced C-F Bond Activation (Project Head Hopkinson, Matthew )
• A06 - Fluorine-Specific Interactions in Fluorinated Coordination Polymers for Electrocatalysis - Proton Conduction and Catalytic Activity for Fuel-Cells and Water Electrolysis (Project Heads Emmerling, Franziska ;  Roth, Christina )
• B02 - Control of Spin States at Metal Centers through Fluorine-Specific Interactions in the Secondary Coordination Sphere (Project Head Sarkar, Biprajit )
• B05 - Controlling the Activation of CO2 and H2 by Fluorine-Specific Interactions at Lewis-acidic Interfac-es (Project Head Frei, Elias )
• B07 - Spin State Control of Organometallic Fe(IV) Compounds through Interactions with Fluoride and Fluoride-Containing Ligands (Project Head Malischewski, Moritz )
• C01 - Indigoswitches to Quantify Fluorine‐Specific Interactions (Project Head Hecht, Stefan )
• C03 - Characterization of Fluorine-Specific Interactions in the Gas Phase (Project Head Pagel, Kevin )

Applicant Institution Freie Universität Berlin

Participating University Humboldt-Universität zu Berlin; Technische Universität Berlin

Participating Institution Bundesanstalt für Materialforschung und -prüfung (BAM); Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
im Forschungsverbund Berlin e.V.

Spokesperson Professor Dr. Sebastian Hasenstab-Riedel