The organization of structural lipids in synaptic membranes (B01)

• Subject Area: Biophysics
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

The lipid composition of the synapse has been difficult to study. Structural lipids, including abundant phospholipids, cholesterol or sphingolipids, are poorly understood. Their concentrations in synaptic membranes are unclear, and their distributions are virtually unknown. I propose to approach this problem by combining two state-of-the-art lipid analysis tools, based on secondary ion mass spectrometry (SIMS): time-of-flight SIMS (ToF-SIMS), and nanoscale SIMS (NanoSIMS).

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Dr. Thi Ngoc Nhu Phan