Metabolic impact on chromatin dynamics - understanding control of gene expression through metabolic enzymes and their products
(A20)
Subject Area
Biochemistry
Term
from 2017 to 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 213249687
Most chromatin modifiers require co-factors that are metabolic intermediates. To understand mechanistically the cross-talk between metabolism and chromatin we will (i) manipulate selected metabolic enzymes that produce or convert co-factors to unravel their impact on histone PTMs locally and globally (ii) recruit metabolic enzymes to genes to reveal - in combination with in vitro reconstitutions - their effect on transcription and (iii) identify (nuclear) interactions between histone modifiers and metabolic enzymes as well as their genomic location. This will give us important insights in how metabolic enzymes impact histone PTMs and how chromatin responds to metabolic challenges.
DFG Programme
Collaborative Research Centres
