Nano-particular mRNA-carrier systems to reprogram different immune-cell populations (B12)

• Subject Area: Pharmacy
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

Aim of TP B12 is the development of medically applicable nanoparticular delivery systems to allow func-tional modulation of T- and NK-cells by mRNA-coding cytokines. RNA-Lipoplex-NP initially developed by Sahin et al. are already investigated in clinical studies for the treatment of melanoma. To further expand the concept of mRNA based immune therapies onto T- and NK-cells polymer-lipid-hybrid and ligand systems were established and will be further developed regarding their clinical translation for immune therapies of melanoma.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Major Instrumentation: NanoAssembler
• Instrumentation Group: 5091 Rasterkraft-Mikroskope
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Matthias Barz; Professor Dr. Peter Langguth; Professor Dr. Ugur Sahin