Aim of TP B12 is the development of medically applicable nanoparticular delivery systems to allow func-tional modulation of T- and NK-cells by mRNA-coding cytokines. RNA-Lipoplex-NP initially developed by Sahin et al. are already investigated in clinical studies for the treatment of melanoma. To further expand the concept of mRNA based immune therapies onto T- and NK-cells polymer-lipid-hybrid and ligand systems were established and will be further developed regarding their clinical translation for immune therapies of melanoma.
DFG Programme
Collaborative Research Centres
Major Instrumentation
NanoAssembler
Instrumentation Group
5091 Rasterkraft-Mikroskope
