Proteins on nanocarriers: from the stealth effect to active targeting in vivo (B11*)

• Subject Area: Pharmacy
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

Starting with the observation that some nanocarriers build up a protein corona nearly instantaneous-ly in context with serum proteins, which has serious results for cellular uptake and intra-cellular trafficking, this project aims at three different topics. At first it will study possible corona formation on more carrier systems to determine the generality of this phenomenon. Then the applicants want to look for ways to pre-organize desired proteins in the corona to modify biodistribution. At last it is the aim to bind desired proteins like clusterin and/or antibodies chemically to obtain –in this way- a stealth like behavior.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Co-Applicant Institution: Max-Planck-Institut für Polymerforschung
• Project Heads: Professor Dr. Volker Mailänder; Professor Dr. Stefan Tenzer; Professorin Dr. Tanja Weil