Characterization of the human NoCut pathway

• Applicant: Dr. Patrick Steigemann
• Subject Area: Cell Biology
• Term: from 2006 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 36514477

• Final Report Year: 2009

Final Report Abstract

Dividing cells need to first segregate the complete set of replicated chromosomes and then split into two daughter cells by a process termed cytokinetis. Failures in cytokinesis result in a tetraploid state with supernumerary copy numbers of chromosomes. This can lead to abnormal cell proliferation and is suspected to promote cancerogenesis. We identified a new celt division control mechanism in human cells that coordinates the timing of chromosome segregation and the last step of cytokinetis, abscission. This mechanism protects cells with delayed chromosome segregation against tetraploidization.

Publications

• Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidizati on, Cell (2009)
  Steigemann et al.
  (See online at https://doi.org/10.1016/j.cell.2008.12.020)