Modular assembly, plasma membrane targeting and regulation of KCNQ (Kv7) K+ channels (C04)

Subunit-specific assembly of human KCNQ (Kv7) channels is determined by a carboxy-terminal domain, which contains two coiled-coil sequences. This project aims at the clarification of molecular determinants within the KCNQ C-termini, which drive the modular assembly of KCNQ subunits into functional channels, determine the efficiency of transport of channel modules to the plasma membrane, and mediate interactions with regulatory proteins. Analysis guided by the modular concept will resolve the complexity of KCNQ channel assembly and regulation in excitable cells, with implications on K+ channel biophysics to neurophysiology.

DFG-Verfahren Sonderforschungsbereiche

Teilprojekt zu SFB 740:  Von Molekülen zu Modulen: Organisation und Dynamik zellulärer Funktionseinheiten

Antragstellende Institution Gemeinsam FU Berlin und HU Berlin durch:
Charité - Universitätsmedizin Berlin

Mitantragstellende Institution Technische Universität Berlin

Teilprojektleiter Professor Dr. Thomas Friedrich