Project Details
Projekt
KFO 196: Signal Transduction in Adaptive and Maladaptive Cardiac Remodelling
Subject Area
Medicine
Biology
Biology
Term
from 2007 to 2015
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 35635434
Chronic heart failure is a rapidly growing health problem in the industrialised countries and represents the most common diagnosis of hospital admission in elderly patients. However, the molecular pathology of chronic heart failure is still incompletely understood and therapeutic options are limited. Similarly, atrial fibrillation is a leading cause of morbidity, the incidence is markedly increased in patients with heart failure and impairs their left ventricular function as well as the clinical outcome. The Clinical Research Unit at the University of Saarland will therefore further characterise the molecular mechanisms of physiologic and pathologic remodelling of the ventricular and atrial myocardium.
The research will focus on the processes of the molecular and cellular phenotype changes during left ventricular hypertrophy and the changes occurring in the hypocontractile ventricle. In addition, the project will address the molecular and electrical changes of the atrial myocardium in the context of myocardial damage and alterations of cardiac load. Therapeutic interventions may be possible by influencing signal transduction cascades. Therefore, the aim of the Clinical Research Unit is to understand the detailed membrane, cytosolic and mitochondrial signalling cascades. The research projects will combine basic research and applied studies in order to identify novel potential targets to prevent and treat maladaptive cardiac remodelling.
The research will focus on the processes of the molecular and cellular phenotype changes during left ventricular hypertrophy and the changes occurring in the hypocontractile ventricle. In addition, the project will address the molecular and electrical changes of the atrial myocardium in the context of myocardial damage and alterations of cardiac load. Therapeutic interventions may be possible by influencing signal transduction cascades. Therefore, the aim of the Clinical Research Unit is to understand the detailed membrane, cytosolic and mitochondrial signalling cascades. The research projects will combine basic research and applied studies in order to identify novel potential targets to prevent and treat maladaptive cardiac remodelling.
DFG Programme
Clinical Research Units
Projects
- Bedeutung Gq/11 gekoppelter Signalwege für das kardiale Remodeling (Applicant Lipp, Ph.D., Peter )
- Identifizierung und Charakterisierung von zellulären Mechanismen und genetischen Determinanten der kardialen und systemischen Fibrogenese (Applicant Lammert, Frank )
- Mineralokortikoid-induziertes atriales Remodeling (Applicant Neuberger, Hans-Ruprecht )
- Mitochondriale antioxidative Kapazität bei kardialem Remodeling (Applicant Maack, Christoph )
- Rolle von Integrin-Linked Kinase- und Toll-Like Rezeptormediierter Signaltransduktion für die Rekrutierung und Aktivierung mononukleärer Zellen bei myokardialem Remodeling (Applicant Schirmer, Stephan )
- Rolle von TRP-Kanälen beim kardialen Remodelling (Applicant Freichel, Marc )
- Signaltransduktion im Rahmen von atrialem Remodelling (Applicant Laufs, Ulrich )
- Zentralprojekt "Z-Projekt" (Applicant Böhm, Michael )
Spokesperson
Professor Dr. Michael Böhm
Leader
Professor Dr. Ulrich Laufs
