Project Details
Projekt
Motor-driven transport of intracellular cargo: cooperativity and control (A09)
Subject Area
Biophysics
Term
since 2017
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 200049484
In this project we address several aspects of the cooperative dynamics of molecular motors. We analyze, both experimentally and theoretically, the dynamics of rigid and vesicular cargo which is propelled by teams of dynein and kinesin motors along microtubules (MTs). The knowledge gained in this part of the project will be applied to identify possible strategies for external motility control in intracellular and artificial transport systems. We will focus on the influence of posttranslational modifications of MTs on the motor-dynamics, as well as on the mechanical properties of motor-driven MTs.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität des Saarlandes
Project Heads
Professor Dr. Stefan Diez; Professor Dr. Ludger Santen
