Protein quality control and ECM composition: Role of the hexosamine pathway in skin homeostasis (B14*)

• Subject Area: Dermatology
• Term: from 2017 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208

In this project we will find out if modulation of the hexosamine pathway is a viable route to improve skin homeostasis. We have shown that activation of the hexosamine pathway improves protein folding and enhances the production of essential ECM components. We aim to reach a molecular understanding of the relevant changes in the skin regarding regeneration, wound healing, protection from fibrosis, and stem cell dynamics.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 829: Molecular Mechanisms Regulating Skin Homeostasis
• Applicant Institution: Universität zu Köln
• Co-Applicant Institution: Max-Planck-Institut für Biologie des Alterns
• Project Head: Dr. Martin Denzel