Protein quality control and ECM composition: Role of the hexosamine pathway in skin homeostasis (B14*)

In this project we will find out if modulation of the hexosamine pathway is a viable route to improve skin homeostasis. We have shown that activation of the hexosamine pathway improves protein folding and enhances the production of essential ECM components. We aim to reach a molecular understanding of the relevant changes in the skin regarding regeneration, wound healing, protection from fibrosis, and stem cell dynamics.

DFG Programme Collaborative Research Centres

Subproject of SFB 829:  Molecular Mechanisms Regulating Skin Homeostasis

Applicant Institution Universität zu Köln

Co-Applicant Institution Max-Planck-Institut für Biologie des Alterns

Project Head Dr. Martin Denzel