Lipid accumulation mechanisms and their modulation (B10)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Pediatric and Adolescent Medicine
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838

We will use lipoma as model for aberrant lipid accumulation and inhibit target molecules identified in the previous funding period (PIK3CA, PDE3/4/8, MAOA). Further, we will inquire sequencing data from human lipomas and human obesity databases to identify novel genes involved in adipocyte development and lipid accumulation. We will assess whole-body energy metabolism and characterize differences in adipose tissue between lipoma-bearing and control mice to identify factors involved in adipose tissue remodeling.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1052: Obesity Mechanisms
• Applicant Institution: Universität Leipzig
• Project Heads: Dr. Antje Garten; Professor Dr. Wieland Kiess, until 6/2021; Dr. Gabriela-Diana Le Duc, since 7/2021