Lipid accumulation mechanisms and their modulation
(B10)
Subject Area
Endocrinology, Diabetology, Metabolism
Pediatric and Adolescent Medicine
Term
from 2017 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838
We will use lipoma as model for aberrant lipid accumulation and inhibit target molecules identified in the previous funding period (PIK3CA, PDE3/4/8, MAOA). Further, we will inquire sequencing data from human lipomas and human obesity databases to identify novel genes involved in adipocyte development and lipid accumulation. We will assess whole-body energy metabolism and characterize differences in adipose tissue between lipoma-bearing and control mice to identify factors involved in adipose tissue remodeling.
DFG Programme
Collaborative Research Centres
