Role of the phospholipid hydroxyperoxide glutathion peroxidase (PHGPx) GPx4 in murine hepatozytes and hepatocarcinogenesis
(A22*)
Subject Area
Gastroenterology
Term
from 2017 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463
Glutathion-Peroxidase 4 is part of the anti-oxidant system of the cell and a loss can trigger a specific form of cell death, namely ferroptosis. Aim of this new project is the investigation of role of GPx4 in the liver using hepatocyte specific GPx4 knockout mice. Another focus lies on investigating the GPx4-dependent ferroptosis in transposon based models of hepatocarcinogenesis and non-alcoholic steatoheapatitis (NASH) using suitable genetic mouse models.
DFG Programme
Collaborative Research Centres
