Structural and functional factors determining entry and replication of hepatitis D and B viruses during co-infection (B08)

• Subject Area: Virology
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 197785619

The project aims to investigate structural and functional factors that are important for entry and replication of the human pathogenic RNA satellite virus HDV and its helper virus HBV. The project will provide more detailed molecular and mechanistic insights into the internalization process of the virus-receptor complex that is triggered by HDV/HBV binding to the receptor NTCP. In addition, the replication cycle of HDV will be analyzed in comparison with other, recently identified animal HDV that are phylogenetically closely related to human HDV. All these processes will be analyzed under mono- and co-infection conditions with different hepatotropic viruses (HBV, HDV, HCV).

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1021: RNA Viruses: RNA Metabolism, Host Response and Pathogenesis
• Applicant Institution: Philipps-Universität Marburg
• Co-Applicant Institution: Justus-Liebig-Universität Gießen
• Project Heads: Professor Dr. Joachim Geyer; Professor Dr. Dieter Glebe