The role of suburothelial myofibroblasts and afferent nerve fibres as mediators of bladder sensation and as possible drug targets in detrusor overactivity.

• Applicant: Professor Dr. Alexander Roosen
• Subject Area: Reproductive Medicine, Urology
• Term: from 2006 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32643384

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• (2007). Urothelial targets in the overactive bladder. Journal für Urologie und Urogynäkologie, 14: 20-23
  Fry CH, Roosen A
  
• Adreno-muscarinic synergy in the bladder trigone: Calcium-dependent and -independent mechanisms. Cell Calcium. 2008 Jun 30
  Roosen A, Fry CH, Sui G, Wu C
  
• Characteristics of Spontaneous Activity in the Bladder Trigone. Eur Urol. 2008 Jun 20 [Epub ahead of print]
  Roosen A, Wu C, Sui G, Chowdhury RA, Patel PM, Fry CH
  
• Editorial Comment on: Bladder Angiotensin-II Receptors: Characterization and Alteration in Bladder Outlet Obstruction. Eur Urol. 2008 Mar 19
  Roosen A
  
• Editorial Comment on: TGF-beta1 Inhibits Cx43 Expression and Formation of Functional Syncytia in Cultured Smooth Muscle Cells from Human Detrusor. Eur Urol. 2008 Apr 3
  Roosen A, Fry CH
  
• Modulation of bladder myofibroblast activity: implications for bladder function. Am J Physiol Renal Physiol. 2008 Sep; 295(3): F688-97
  Sui GP, Wu C, Roosen A, Ikeda Y, Kanai AJ, Fry CH
  
• Synergistic effects in neuromuscular activation and calcium-sensitisation in the bladder trigone. BJU Int. 2008 Mar;101(5):610-4
  Roosen A, Wu C, Sui GP, Fry CH