Identification of miRNA Targeting Hierarchies in Lymphocyte Development (B15)

Subject Area Immunology
Term from 2016 to 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 161793742
 

Project Description

Post-transcriptional gene regulation by miRNAs plays a fundamental role in many biological processes. The molecular mechanisms of miRNA function and target recognition are only partially understood. Using T-cell development as a defined physiologic model in combination with light-inducible tools and functional genomics, we will address fundamental questions how miRNAs repress a distinct set of functionally relevant target genes in the presence of an overall excess of miRNA response elements.
DFG Programme Collaborative Research Centres
Subproject of SFB 902:  Molecular Principles of RNA-based Regulation
Applicant Institution Goethe-Universität Frankfurt am Main
Project Head Professor Dr. Andreas Krueger