Molecular switches in the synchronization of the circadian oscillator
(A17)
Subject Area
Bioinformatics and Theoretical Biology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 278001972
In project A17, fundamental cell biological processes that occur when the cellular circadian clock is switched to a new state by an acute zeitgeber pulse will be elucidated, e.g. the molecular number and complex size of individual components, the complex assembly, and which components directly interact with each other. We combine new CRISPR-generated knock-in reporter cell lines with a variety of advanced single-cell fluorescence microscopy techniques (e.g. fluorescence (cross)correlation spectroscopy, FLIM-FRET).
DFG Programme
CRC/Transregios
