Ubiquitin-dependent coordination of mitochondrial-cytoplasmic quality control
(B03)
Subject Area
Cell Biology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409
Ubiquitin-dependent degradation of outer mitochondrial membrane (OMM) proteins has been implicated in the dynamic regulation of mitochondrial-cytosolic communication, but little is known about its mechanistic regulation and physiological consequences. To monitor OMM protein turnover in a multicellular organism, we developed a fluorescent reporter assay in C. elegans based on an OMM-anchored GFP-tagged reporter substrate. The main goal of the proposed research is to understand how physiological and metabolic changes regulate ubiquitin-dependent OMM protein degradation in an organismal context.
DFG Programme
Collaborative Research Centres
