The role of CLUH in the translation of mRNAs encoding mitochondrial proteins
(A05)
Subject Area
Cell Biology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409
Regulation of mitochondrial biogenesis and function is essential during development and adult life. Post-transcriptional mechanisms enable fast and adaptive responses to tailor mitochondrial gene expression to changing cellular needs. We showed that the CLUH (clustered mitochondrial homolog) protein binds mRNAs encoding for a subset of mitochondrial proteins. Loss of CLUH leads to destabilization of its target mRNAs and to a depletion of the corresponding proteins from mitochondria. Previously, we have demonstrated the physiological requirement of CLUH in the mouse in several tissues. We now aim to elucidate the molecular basis of how CLUH binds and regulates its target mRNAs.
DFG Programme
Collaborative Research Centres
