Regulation and function of POLG-mediated mtDNA degradation (A04)

Autophagy is a highly conserved process required for cellular homeostasis during basal and stress conditions. Defects in autophagy result in the degradation of mitochondrial genomes (mtDNA) via a novel mechanism. The mitochondrial DNA polymerase gamma catalyzes not only the synthesis but also the degradation of mtDNA via its inherent 3’-5’ exonuclease activity. Within this project, we are examining the cellular mechanisms regulating the balance of the synthetic and degradative activities of POLG. In addition, we are characterizing the physiological consequences of POLG-mediated mtDNA degradation.

DFG Programme Collaborative Research Centres

Subproject of SFB 1218:  Mitochondrial regulation of cellular function

Applicant Institution Universität zu Köln

Co-Applicant Institution Max-Planck-Institut für Biologie des Alterns

Project Heads Dr. Martin Graef, until 2/2022; Professor Dr. Thomas Langer, since 3/2022