Cellular quality control by mitofusins and ubiquitin
(A03)
Subject Area
Cell Biology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409
Mitochondrial plasticity contributes to protein quality and neuronal integrity. Mitofusins, mitochondrial fusion factors, can sense and respond to many different stimuli through their ubiquitylation. We recently reported on a ubiquitin-dependent proteolytic stress response at the mitochondrial surface that merges these many different signals into a common cellular response. Now we wish to further explore this quality control pathway and unravel how mitofusins and ubiquitin support cellular triage of damaged mitochondrial components. Our project aims to elucidate molecular mechanisms providing protection to mitochondria under stress.
DFG Programme
Collaborative Research Centres
