Proteolytic control of mitochondrial dynamics and metabolism by OMA1 (A01)

Mitochondria are dynamic and functionally plastic organelles that adapt to different physiological requirements. The mitochondrial peptidase OMA1 coordinates mitochondrial stress responses at the interface of mitochondrial dynamics, metabolism and cell survival. The current project analyses cell- and context-specific OMA1-mediated stress responses using various mouse models and employs unbiased systems approaches to identify novel OMA1-mediated mitochondrial stress responses.

DFG Programme Collaborative Research Centres

Subproject of SFB 1218:  Mitochondrial regulation of cellular function

Applicant Institution Universität zu Köln

Co-Applicant Institution Max-Planck-Institut für Biologie des Alterns

Project Head Professor Dr. Thomas Langer