High-resolution multiparametric cell and tissue analysis & establishment of a spatially resolved cell atlas of the chronically hepatitis B virus infected liver (Z02)

• Subject Area: Medicine
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 272983813

Project Z02 provides cutting-edge expertise for analyses of high-resolution single-cell level histology, mass cytometry and spatial transcriptomics for the members of the consortium. In addition to various support offers such as a slide consultation service by an expert pathologist, histology staining and guidance from conceptualization to analysis of mass cytometry experiments, incl. method and data analysis training, this project will further develop spatial single-cell level multiomics methods. Specifically, Z02, in close collaboration with Z03, will work towards a spatially resolved multiomics cell atlas of the HBV infected liver by integrating multiple spatial omics approaches such as spatial proteomics, spatial transcriptomics and spatial metabolomics.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 179: Determinants and dynamics of elimination versus persistence of hepatitis virus infection
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Immanuel Anton Andrä, until 6/2024; Dr. Tanja Bauer, until 6/2020; Professor Bertram Bengsch, Ph.D., since 7/2020; Professor Dr. Roland Eils, until 6/2020; Professorin Dr. Carolin Mogler, since 7/2020; Professor Dr. Christoph Neumann-Haefelin, until 6/2020; Dr. Matthias Schiemann, until 6/2024