Project Details
Projekt
Contribution of innate immune responses to persistence versus clearance of hepatitis C and hepatitis A virus infections (17)
Subject Area
Virology
Immunology
Immunology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 272983813
We will continue to study the role of ESCRT in dsRNA secretion and unravel the cellular determinants of HCV recognition by TLR3. For HAV, we aim to identify protease-independent mechanism(s) blunting the cell intrinsic innate immunity in vivo and in vitro, with a focus on the viral protein 2B. Finally, we will study the contribution of viral replication fitness on the outcome of HCV and HAV infections. Our results will ultimately disentangle the complex relationship between viral replication, immune induction and counteraction goverining persistence versus clearance of hepatotropic viruses.
DFG Programme
CRC/Transregios
Subproject of
TRR 179:
Determinants and dynamics of elimination versus persistence of hepatitis virus infection
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Head
Professor Dr. Volker Lohmann
