Dynamics of anti-viral immunity against viral infection of the liver
(13)
Subject Area
Virology
Immunology
Term
since 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 272983813
Using sophisticated in vivo HBV infection models, we are able to trace adaptive immunity in real-time. With this, we have demonstrated that innate immunity stimulation is able to overcome dysfunctional CD8 T cells during chronic HBV infection and to restore anti-HBV immunity leading to clearance of the infection. Using single cell RNA sequencing, we identified a Tcf7+ progenitor cell population within the liver. Stimulation of these progenitor cells in a type I interferon dependent manner, leads to their proliferation and differentiation into effector cells eliminating HBV replicating hepatocytes. We now study in detail the intrahepatic localisation of those Tcf7+ progenitor cells and their functional properties.
DFG Programme
CRC/Transregios
