Identification of systems properties determining the dynamics of the hepatitis B virus infection cycle and cross-talk to host cell responses (10)

• Subject Area: Virology
• Term: from 2016 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 272983813

The dynamics of the cross-talk of the HBV infection cycle with host cell responses is studied by quantitative mass spectrometry. Based on this data a mathematical model of the HBV infection cycle is calibrated and will be linked to a dynamic pathway model of interferon (IFN)α induced antiviral responses. The aim is to identify mechanisms responsible for the synergistic effects of Myrcludex B (MyrB) and pegylated IFNα (PEG-IFNα) that was observed in clinical trials and thereby provide means to identify patients that might particularly benefit from the co-treatment of MyrB and PEG-IFNα.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 179: Determinants and dynamics of elimination versus persistence of hepatitis virus infection
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professorin Dr. Ursula Klingmüller; Professor Dr. Jens Timmer