Project Details
Projekt
Influence of a decentralized biobanking concept on the quality of stored biomaterial samples
Applicant
Privatdozentin Dr. Karoline I. Gaede
Subject Area
Epidemiology and Medical Biometry/Statistics
Term
from 2016 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 315096949
Networked biomedical research projects require a high degree of interoperability between universities, other academic organizations and non-academic institutions. The cooperation becomes even more complex in a decentralized infrastructure as pursued within the German Centres for Health Research (DZGs) or in collaborations between DZGs.Biomaterial samples are ideally collected centrally using harmonized infrastructure and processes. A number of national epidemiological studies exist (e.g. KORA, SHIP, PopGen, National Cohort) build on a comprehensive, quality-assured sample pool and data on phenotypes. However, the phenotypic data of these cohorts are often insufficient for specific questions e. g. in pneumology. Such cohorts often have a small spectrum of specific sample types e.g. lavage fluid or others. Moreover, sample requests can often be expected with a perennial flow.The proposed research project of BMB North in Borstel, the HUB in Hannover, PopGen in Kiel, the ICB-L in Lübeck, the IRB in Greifswald and the IBBJ in Jena is rooted in a cooperative grounding project of the Research Centre Borstel in pneumology. The initial motivation was the generation of reference values of healthy individuals. Within the project presented here, recruiting of voluntary healthy subjects (n = 250) at five differently structured sites is planned, using different recruitment strategies. Specimen collection, -processing, management, storage and transport will be adapted to decentralize the infrastructure of differently equipped biobanks. Objectives of the research project are (I) the provision of high quality biomaterials facilitating inter-site comparability, (II) the central analysis of samples obtained decentrally through a separate analysis method at each of the sites. This results in the determination of reference values for scientific purposes, (III), the identification of critical factors for decentralized recruitment, extraction and processing of samples, followed by the development of recommendations, guidelines and standards, which will be published according to internationally standards.The project reflects current challenges of biobanks in research networks that are repeatedly discussed within the TMF working groups. This expertise in the TMF working groups will be sought in order to optimize the proposed projects and its outcome. The high degree of interconnectivity of the project allows the participation and cooperation of all partners in the TMF working groups and DZGs that have a focus on pulmonary research. Project participants are members of biobanks and are cooperating within frameworks of the DZL, the DZIF, the DZHK of P2N and Norddeutsche Biobanken Allianz for many years.
DFG Programme
Research Grants
