Importance of mitochondrial ROS and substrate metabolism for the development and progression of right heart failure (B05)

• Subject Area: Anatomy and Physiology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 268555672

In wildtype and knockout mouse (monoamine oxidase, MAO) and rat (uncoupling protein 2) models of right ventricular stress (PH, pulmonary artery banding, exercise in hypertensive rats, volume load) the regulation and interaction of enzymes involved in shifting oxidative glucose metabolism to glycolysis - thereby feeding branch pathways required for right ventricular (RV) failure - will be analyzed. The relationship between MAO-dependent substrate availability through increased numbers of inflammatory cells and substrate utilization for increased oxidative stress and subsequent development of RV failure will be assessed. It will be clarified whether blockade of MAO reverses PH-induced cardiac alterations even after first symptoms of the disease have developed.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1213: Pulmonary Hypertension and Cor Pulmonale
• Applicant Institution: Justus-Liebig-Universität Gießen
• Project Heads: Professor Dr. Klaus-Dieter Schlüter; Professor Dr. Rainer Schulz