Control of pulmonary vessels and the right heart by histone modifications and metabolism in development and disease (B02)

• Subject Area: Cardiology, Angiology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 268555672

Epigenetic dysregulations and subsequent developmental abnormalities caused by Suv4-20h1 inactivation predispose for chronic lung diseases such as COPD and PH, leading to right ventricular (RV) hypertrophy and/or dilation. To gain better insights into underlying molecular mechanisms and implication in disease intervention, we will explore the molecular events regulating Suv4-20h1 activity and function during pathogenesis, decipher the function of Suv4-20h1 in PDGFR+ stromal cells during lung maturation and injury repair, and investigate the interplay between epigenetics and metabolism in regulating RV-remodeling and function during PH pathogenesis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1213: Pulmonary Hypertension and Cor Pulmonale
• Applicant Institution: Justus-Liebig-Universität Gießen
• Project Heads: Professor Dr. Thomas Braun; Dr. Xuejun Yuan; Dr. Yonggang Zhou, Ph.D., until 4/2016 (†)