Inflammatory lung microenvironment in lung cancer-associated pulmonary hypertension (A08)

• Subject Area: Pneumology, Thoracic Surgery
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 268555672

Structural remodeling of the lung vasculature is a hallmark of pulmonary hypertension and is characterized by a “pseudo-malignant” cellular phenotype. Those pathobiological alterations are governed by kinases that stimulate signaling pathways involved in cell survival and growth as well as resistance to apoptosis. Spatiotemporal analysis of the kinome atlas in the lung as well as in the right ventricle will reveal a unique 3D landscape of potential new drug targets. Therefore, we seek to therapeutically exploit this class of proteins by using kinase inhibitors targeting disease-driving pulmonary vascular cells as well as peripheral blood mononuclear cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1213: Pulmonary Hypertension and Cor Pulmonale
• Applicant Institution: Justus-Liebig-Universität Gießen
• Project Heads: Professor Dr. Hossein Ardeschir Ghofrani; Professor Dr. Friedrich Grimminger, until 6/2024; Professor Dr. Ralph Schermuly, until 6/2024; Dr. Astrid Weiß