TRR 205: The Adrenal: Central Relay in Health and Disease
Subject Area
Medicine
Agriculture, Forestry and Veterinary Medicine
Biology
Chemistry
Term
since 2017
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271
Project Description
No abstract available
DFG Programme
CRC/Transregios
International Connection
France, Switzerland, United Kingdom
Current projects
A01 - Regulated cell death in adrenal inflammation and septic shock
(Project Heads
Bornstein, Stefan R.
;
Kanczkowski, Waldemar
;
Linkermann, Andreas
)
A02 - The impact of hypoxia pathway proteins on the adrenergic response in the adrenal gland and beyond
(Project Heads
Chavakis, Triantafyllos
;
El-Armouche, Ali
;
Wielockx, Ph.D., Ben
)
A04 - In vitro and in vivo models of novel therapeutic approaches in congenital adrenal hyperplasia
(Project Heads
Hübner, Ph.D., Angela
;
Köhler, Katrin
;
Reisch, Nicole
)
A05 - Biological treatment of adrenal insufficiency by encapsulated xenogeneic adrenal cells
(Project Heads
Bornstein, Stefan R.
;
Ludwig, Barbara
)
A06 - Adrenal stem cells under homeostatic and stress conditions
(Project Heads
Andoniadou, Ph.D., Cynthia L.
;
Bornstein, Stefan R.
;
Schedl, Andreas
;
Steenblock, Charlotte
)
A07 - Immunometabolic regulation of adrenal glucocorticoid production and peripheral glucocorticoid signalling
(Project Heads
Alexaki, Vasileia Ismini
;
Eaton, Suzanne
;
Henneicke, Ph.D., Holger
)
A08 - Adrenal gland – crossroads of stress response – epigenetic, transcriptional, and metabolic analyses
(Project Heads
Chen, Alon
;
Riester, Anna
;
Sbiera, Ph.D., Silviu
)
A09 - Sexual dimorphism of adrenal hormone action in metabolic tissues
(Project Heads
Herzig, Stephan
;
Uhlenhaut, Nina Henriette
)
B10 - Targeting radio- and chemo-resistance in metastatic phaeochromocytoma/ paraganglioma
(Project Heads
Pietzsch, Jens
;
Richter, Ph.D., Susan
;
Ziegler, Ph.D., Christian G.
)
B11 - The molecular pathology of PPGLs and genetically-driven molecular-targeted therapies: Towards precision medicine
(Project Heads
Nölting, Svenja
;
Pellegata, Natalia S.
)
B12 - HIF-MYC/MAX pathway in neural-crest derived catecholamine producing tumours: Identification of a metabolic fingerprint related to tumour aggressiveness
(Project Heads
Bechmann, Nicole
;
Eisenhofer, Ph.D., Graeme
;
Klink, Barbara
;
Lenders, Ph.D., Jacques W.M.
)
B13 - Genetic and environmental contributors to vascular function in primary aldosteronism
(Project Heads
Fuß, Carmina Teresa
;
Hahner, Stefanie
;
Reincke, Martin
;
Schirbel, Andreas
)
B14 - Identification and functional characterisation of genetic contributors to primary aldosteronism
(Project Heads
Beuschlein, Felix
;
Gudermann, Thomas
;
Reincke, Martin
;
Schneider, Holger
)
B15 - Pathophysiology and advanced approaches for subtyping in primary aldosteronism
(Project Heads
Eisenhofer, Ph.D., Graeme
;
Lenders, Ph.D., Jacques W.M.
;
Williams, Ph.D., Tracy Ann
)
B16 - Steroid hormones and cancer immunity – learning from adrenocortical carcinoma
(Project Heads
Fassnacht, Martin
;
Kroiß, Ph.D., Matthias
)
B17 - Molecular pathology and treatment of Cushing’s disease
(Project Heads
Reincke, Martin
;
Theodoropoulou, Marily
)
B19 - The physiology and pathophysiology of aldosterone production in the pig
(Project Heads
Kemter, Elisabeth Gabriele
;
Williams, Ph.D., Tracy Ann
;
Wolf, Eckhard
)
B20 - Targeting ferroptosis in adrenocortical carcinoma (ACC): from basic mechanisms to novel treatments
(Project Heads
Friedmann Angeli, José Pedro
;
Kroiß, Ph.D., Matthias
;
Weigand, Isabel
)
INF - Infrastructure for adrenal research
(Project Heads
Beuschlein, Felix
;
Eisenhofer, Ph.D., Graeme
;
Fassnacht, Martin
;
Müller-Pfefferkorn, Ralph
;
Reisch, Nicole
)
S01 - Analytical platform
(Project Heads
Alves, Tiago
;
Bidlingmaier, Martin
;
Kurlbaum, Max
;
Peitzsch, Mirko
;
Walch, Axel Karl
)
S02 - Patient cohorts and biobanks
(Project Heads
Eisenhofer, Ph.D., Graeme
;
Fassnacht, Martin
;
Pamporaki, Ph.D., Christina
;
Reincke, Martin
)
Z01 - Central Task
(Project Head
Bornstein, Stefan R.
)
Completed projects
A03 - Understanding the mechanisms leading to autoimmune adrenalitis by generating the first experimental animal model
(Project Head
Chavakis, Triantafyllos
)
Applicant Institution
Technische Universität Dresden
Co-Applicant Institution
Julius-Maximilians-Universität Würzburg
;
Ludwig-Maximilians-Universität München
Spokesperson
Professor Dr. Stefan R. Bornstein
