Investigation of the molecular mechanisms and interplay of TTP-mediated mRNA decay and translational repression using structural and biochemical tools

Applicant Professorin Sutapa Chakrabarti, Ph.D.

Subject Area General Genetics and Functional Genome Biology
Biochemistry
Structural Biology

Term from 2016 to 2024

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 313425078

No abstract available

A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner. Nucleic Acids Research, 46(5), 2648-2659.
Gowravaram, Manjeera; Bonneau, Fabien; Kanaan, Joanne; Maciej, Vincent D; Fiorini, Francesca; Raj, Saurabh; Croquette, Vincent; Le Hir, Hervé & Chakrabarti, Sutapa
Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA. Nucleic Acids Research, 50(18), 10665-10679.
Maciej, Vincent D; Mateva, Nevena; Schwarz, Juliane; Dittmers, Theresa; Mallick, Megha; Urlaub, Henning & Chakrabarti, Sutapa
Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2. RNA, 29(2), 178-187.
Xue, Guangpu; Maciej, Vincent D.; Machado de Amorim, Alexandrina; Pak, Melis; Jayachandran, Uma & Chakrabarti, Sutapa

Servicenavigation