Astrocyte-specific function of OTUB1 in experimental autoimmune encephalomyelitis

Final Report Abstract

We have completed the project successfully. The key findings of this project are: OTUB1 expression is induced in astrocytes of MS patients and EAE mice. - OTUB1 ablation in astrocytes aggravates EAE. - OTUB1 suppresses IFN-γ-induced chemokine production by astrocytes. - OTUB1 inhibits IFN-γ-induced JAK-STAT1 signaling by deubiquitinating and stabilizing the inhibitor SOCS1.

Publications

• Astrocytes in multiple sclerosis and experimental autoimmune encephalomyelitis: Star-shaped cells illuminating the darkness of CNS autoimmunity. Brain Behav Immun. 2019 May 21
  Yi W, Schlüter D, Wang X
  
• OTUB1 inhibits CNS autoimmunity by preventing IFN-γ-induced hyperactivation of astrocytes. EMBO J. 2019 May 15;38(10)
  Wang X, Mulas F, Yi W, Brunn A, Nishanth G, Just S, Waisman A, Brück W, Deckert M, Schlüter D