Population genetics of hematopoietic neoplasms (A16)

• Subject Area: Bioinformatics and Theoretical Biology ; Evolution, Anthropology ; Hematology, Oncology ; Human Genetics
• Term: from 2016 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 278529602

The development of a tumor can be considered as an evolutionary process. From this point of view, e.g. chemotherapy generates an evolutionary pressure, and the gain of resistance can be understood as evolutionary adaptation in the tumor. We develop theoretical tools to analyze these evolutionary processes in hematopoietic neoplasms, including the role of genetic and epigenetic mutation. For this we adopt approaches of stochastic modeling and of data analysis from evolutionary biology and in particular from population genetics.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1243: Genetic and Epigenetic Evolution of Hematopoietic Neoplasms
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Dirk Metzler