Identifying and targeting escape mechanisms in AML using multispecific antibody derivatives
(A10)
Subject Area
Hematology, Oncology
Biochemistry
Immunology
Term
from 2016 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 278529602
Treatment of AML by allogeneic stem cell transplantation is mediated by T cells but is hampered by a high mortality rate. We find that T-cell function is modulated through progressively evolving changes in phenotype and function of AML and its tumor microen¬vironment (TME). Our goal is to unravel changes in T-cell responses and develop multi-specific antibody derivatives (msADs), tailored to interfere with immune checkpoint molecules in specific geno- and phenotype of AML subtypes.
DFG Programme
Collaborative Research Centres
