The role of human nucleoporins in the remodelling and export of macromolecular complexes (P14)

Subject Area Biochemistry
Term from 2016 to 2019
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 264061860
 

Project Description

The functional specialisation of subcellular compartments in eukaryotic cells requires the regulated exchange of macromolecules to establish and maintain the specific composition of each compartment. Nuclear pore complexes function as gateways between nucleus and cytoplasm and the nucleoporins interact with soluble transport receptors and cofactors during the transport of molecules and complexes. This project analyses the role of nuclear pore complexes in the remodelling and translocation of macromolecular complexes.
DFG Programme Collaborative Research Centres
Subproject of SFB 1190:  Compartmental Gates and Contact Sites in Cells
Applicant Institution Georg-August-Universität Göttingen
Project Head Professor Dr. Markus T. Bohnsack