Project Details
Projekt
Hybrid MR-PET for whole-body staging in breast cancer
Subject Area
Nuclear Medicine, Radiotherapy, Radiobiology
Term
from 2016 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 284319652
According to the current S3 guideline, the conventional imaging algorithm for the staging patients with newly diagnosed breast cancer includes clinical examination, X-ray mammography, breast and axillary ultrasound, a CT thorax / abdomen scan, MRI of the breast to determine local excision margins (only in ultrasound and mammography unclear findings, or in histologically invasive lobular carcinoma, high genetic risk as well as young, premenopausal patients), as well as skeletal scintigraphy.The primary objective of the study is to compare the S3-guideline algorithm to FDG-PET/MRI concerning the relative frequency of therapy changes of the breast due to additional information arising from the FDG PET/MRI scan. Thus, the primary endpoint of the study is the change in the local therapy process. Secondary endpoints are all other therapy changes as a result of whole body FDG-PET/MRI findings. In addition, a comparison of the S3-guidelines algorithm, whole-body MRI, whole-body FDG-PET and whole-body FDG-PET/MRI in terms of diagnostic accuracy (sensitivity, specificity, positive predictive value, negative predictive value, accuracy) for the T, N and M staging and the UICC classification will be performed.
DFG Programme
Research Grants
Co-Investigators
Professor Dr. Ken Herrmann; Professorin Dr. Lale Umutlu
