Organelle-specific autophagy pathways in regulation of cell death
(E09 (C07))
Subject Area
Cell Biology
Hematology, Oncology
Term
from 2016 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777
Autophagy can exert cytotoxic functions which can potentially be utilized for clinical applications including the therapy of apoptosis-refractory tumors such as glioblastoma (GBM). This project aims to reveal the molecular mechanisms by which drug-induced organelle damage engages selective autophagy pathways leading to autophagic cell death and investigate the therapeutic potential of this approach in GBM as a prototypic apoptosis-resistant tumor. To this end, biochemical, cell biological, imaging, and proteomic studies will be combined in preclinical in vitro and in vivo GBM models.
DFG Programme
Collaborative Research Centres