Organelle-specific autophagy pathways in regulation of cell death (E09 (C07))

Subject Area Cell Biology
Hematology, Oncology
Term from 2016 to 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777
 

Project Description

Autophagy can exert cytotoxic functions which can potentially be utilized for clinical applications including the therapy of apoptosis-refractory tumors such as glioblastoma (GBM). This project aims to reveal the molecular mechanisms by which drug-induced organelle damage engages selective autophagy pathways leading to autophagic cell death and investigate the therapeutic potential of this approach in GBM as a prototypic apoptosis-resistant tumor. To this end, biochemical, cell biological, imaging, and proteomic studies will be combined in preclinical in vitro and in vivo GBM models.
DFG Programme Collaborative Research Centres
Subproject of SFB 1177:  Molecular and Functional Characterization of Selective Autophagy
Applicant Institution Goethe-Universität Frankfurt am Main
Project Heads Professorin Dr. Simone Fulda, until 9/2020; Professor Dr. Donat Kögel; Privatdozent Dr. Sjoerd van Wijk, since 10/2020