Organelle-specific autophagy pathways in regulation of cell death (E09 (C07))

Autophagy can exert cytotoxic functions which can potentially be utilized for clinical applications including the therapy of apoptosis-refractory tumors such as glioblastoma (GBM). This project aims to reveal the molecular mechanisms by which drug-induced organelle damage engages selective autophagy pathways leading to autophagic cell death and investigate the therapeutic potential of this approach in GBM as a prototypic apoptosis-resistant tumor. To this end, biochemical, cell biological, imaging, and proteomic studies will be combined in preclinical in vitro and in vivo GBM models.

DFG Programme Collaborative Research Centres

Subproject of SFB 1177:  Molecular and Functional Characterization of Selective Autophagy

Applicant Institution Goethe-Universität Frankfurt am Main

Project Heads Professorin Dr. Simone Fulda, until 9/2020; Professor Dr. Donat Kögel; Privatdozent Dr. Sjoerd van Wijk, since 10/2020