Crosstalk of autophagy and inflammatory signaling pathways during acute intestinal inflammation (C03)

• Subject Area: Cell Biology ; Biochemistry
• Term: from 2016 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777

This project is based on the hypothesis that autophagy factor ATG16L1 represents a direct substrate for IKK¿ in intestinal epithelial cells (IECs) and might control the inflammatory response in acute ulcerative coli-tis. We will employ primary organoid systems derived from mice with defined genetic alterations to describe the exact mode of interaction between IKK¿ and ATG16L1. Moreover, as IKK¿ seems to have contrasting functions in myeloid cells and IECs, we will define the divergent mechanisms that control caspase-1 activity in myeloid cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1177: Molecular and Functional Characterization of Selective Autophagy
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Co-Applicant Institution: Georg-Speyer-Haus; Institut für Tumorbiologie und experimentelle Therapie
• Project Head: Professor Dr. Florian R. Greten