Crosstalk of autophagy and inflammatory signaling pathways during acute intestinal inflammation (C03)

Subject Area Cell Biology
Biochemistry
Term from 2016 to 2019
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777
 

Project Description

This project is based on the hypothesis that autophagy factor ATG16L1 represents a direct substrate for IKK¿ in intestinal epithelial cells (IECs) and might control the inflammatory response in acute ulcerative coli-tis. We will employ primary organoid systems derived from mice with defined genetic alterations to describe the exact mode of interaction between IKK¿ and ATG16L1. Moreover, as IKK¿ seems to have contrasting functions in myeloid cells and IECs, we will define the divergent mechanisms that control caspase-1 activity in myeloid cells.
DFG Programme Collaborative Research Centres
Subproject of SFB 1177:  Molecular and Functional Characterization of Selective Autophagy
Applicant Institution Goethe-Universität Frankfurt am Main
Co-Applicant Institution Georg-Speyer-Haus
Institut für Tumorbiologie und experimentelle Therapie
Project Head Professor Dr. Florian R. Greten