Interplay between autophagy and inflammatory cell death in organ fibrogenesis (F11 (E02))

• Subject Area: Pharmacology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777

Idiopathic pulmonary fibrosis is a frequent fibrotic disease with unresolved pathogenesis. This project builds up on the previous observation that lack-of-function of the autophagy receptor ABIN-1 in mice leads to the development of pulmonary fibrosis. This project will shed light on the interplay between selective autophagy and inflammatory cell death to provide novel pathophysiological concepts and strategies of combined therapies with implications for inflammatory and fibrotic diseases in general.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1177: Molecular and Functional Characterization of Selective Autophagy
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Donat Kögel, since 1/2024; Professorin Dr. Liliana Schaefer