Investigating the links between pathogenicity and antigen specificity of cytotoxic T lymphocytes in crescentic glomerulonephritis (A02)

• Subject Area: Immunology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264599542

In this project we aim at clarifying the contribution of these different types of cytotoxic T lymphocytes (CTLs) to disease pathology of cGN. We will explore the location, interaction partners and cellular targets of cytotoxic CD4+, CD8+ and γδ T cells. Furthermore, we will investigate the specific (auto-)antigens that are recognized by these CTLs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1192: Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications -
• Applicant Institution: Universität Hamburg
• Project Heads: Professor Dr. Stefan Bonn; Dr. Katrin Neumann; Professor Dr. Immo Prinz