Selective autophagy of mitochondria and peroxisomes in organismic aging and development (D07 (B03))

In this project we use the two well-established model organisms Podospora anserina and Caenorhabditis elegans to elaborate the impact of mitophagy and pexophagy on organismic aging and development. We put special emphasis on the role of membrane trafficking factors such as sorting nexins, the Rab GTPase Rab7L1/GLO-1, and the dynamin-related protein DNM1/DRP-1 for these two forms of selective autophagy.

DFG Programme Collaborative Research Centres

Subproject of SFB 1177:  Molecular and Functional Characterization of Selective Autophagy

Applicant Institution Goethe-Universität Frankfurt am Main

Project Heads Professor Dr. Stefan Eimer; Professor Dr. Heinz Dieter Osiewacz