Autophagy in ribosome biogenesis and quality control (D06 (B01)+)

• Subject Area: Biochemistry ; Cell Biology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777

This project follows the idea that premature or defective pre-ribosomes and ribosomes that are generated in the course of ribosome biogenesis are cleared by a specialized selective autophagy pathway termed ribophagy. We aim to dissect the regulatory principles of ribophagy and to identify the selectivity factors involved in distinct ribophagic clearance pathways. Moreover, we aim to analyze the possible impact of ribophagy on pathogenesis of acute myeloid leukemia (AML).

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1177: Molecular and Functional Characterization of Selective Autophagy
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Stefan Müller