Kinetics of metabotropic glutamate receptors (C04)

• Subject Area: Biophysics ; Physical Chemistry of Molecules, Liquids and Interfaces, Biophysical Chemistry
• Term: from 2015 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 258780946

The activation speed of the different G-protein coupled receptors (GPCRs) varies considerably. It has to be taken into account, however, that our present knowledge on the activation speed is most likely biased by methodological limitations. Using three newly established optical techniques the activation speed of all isoforms of metabotropic glutamate receptor GPCR constructs will be analyzed, thereby exploiting Förster Resonance Energy Transfer in specific receptor constructs. Moreover, in adenosine receptors the kinetics of ligand binding will be studied.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 166: High-end light microscopy elucidates membrane receptor function - ReceptorLight
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Klaus Benndorf; Professor Dr. Martin J. Lohse