Spatial organization and dynamics of GPCR signaling as revealed by single-molecule and superresolution microscopy
(C01)
Subject Area
Pharmacology
Term
from 2015 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 258780946
G protein-coupled receptors (GPCRs) constitute the largest family of receptors for hormones and neurotransmitters and represent major pharmacological targets. In this project, we are using high-end optical methods such as single-molecule microscopy and superresolution imaging (dSTORM) to investigate the organization of GPCRs in dynamic nanodomains on the surface of living cells. We expect these experiments to lead to a deeper understanding of the basic mechanisms of GPCR signaling, which might pave the way to innovative and more specific pharmacological therapies for a wide range of human diseases.
DFG Programme
CRC/Transregios
